This Chicken Spaghetti Casserole recipe is the best comfort food casserole recipe! It’s a good dinner recipe for cozy winter nights, and it’s one that the whole family typically enjoys too. Watch the video showing you how to make this Chicken Spaghetti Casserole, then scroll to the bottom of this post and print out the recipe so you can make it at home.

chicken spaghetti casserole in a white dish just out of the oven

When I asked Facebook fans the other day about the possibility of me posting a new casserole recipe, I received an overwhelming response. It seems that there are a lot of casserole-lovers out there! I live in San Diego – not really the Casserole Capital of America. People here eat grilled chicken, tofu hot dogs and salad with no dressing. Casseroles are among the evils that aren’t spoken here in SoCal.

Whatever. I eat casseroles. Must be because all of my distant Swedish relatives live in Minnesota, where comfort food is more welcome. It’s in my genes. And probably my jeans too. The good news is that I lightened up this Chicken Spaghetti Casserole recipe as much as I thought I could.

chicken spaghetti casserole in a white casserole dish

This is quite the cheesy casserole, and I mean that in a good way. It’s hard to lighten up on cheese since low fat cheeses do not tend to melt nicely, so I charged straight ahead and used full-fat cheese for this recipe.

Don’t worry, you’ll see the calorie count in the end (which is actually not too terribly bad).  And you can always use low fat cheese, if you prefer.

ingredients displayed for chicken spaghetti casserole- pasta, cream of mushroom soup, tabasco, cheese, onions, mushrooms, chicken

What ingredients do you need for Chicken Spaghetti Casserole?

Here’s what you’ll need for this recipe. Yep, we’re doing something I rarely do on my recipe site: using Cream of Mushroom Soup. If that scares you, grab my homemade Cream of Mushroom Soup recipe to use instead. If you use my homemade soup, you may not need to add much milk since it’s not a “condensed” version of cream of mushroom.

pasta boiling in water in a pot

How to Make Chicken Spaghetti Casserole:

Boil the pasta, just so it’s kinda al dente (still has a slight bite to it).

melting butter in a skillet

Melt 1 tablespoon of butter in a pan.  Just a tablespoon. We don’t need a whole stick or anything like that since we’re just going to sauté the veggies in it.

sauteing vegetables in a skillet to make chicken spaghetti casserole

Cook the veggies in that melted butter, just until they’re a little bit softened up. Here’s where you can get creative. If you don’t like my choice of veggies (or more importantly, if your family refuses to eat certain veggies), change it up and add in what you’d like.

measuring cup pouring into a bowl to make sauce for chicken spaghetti casserole

Mix nonfat milk with fat-free cream of mushroom soup.

pouring sauce into vegetables in a skillet to make the sauce for chicken spaghetti casserole

Pour that sauce into the veggies.

making sauce for chicken spaghetti casserole in a skillet

Mix it up.

adding cheese to the sauce for chicken spaghetti casserole in a skillet

Add cheese.  I use extra sharp cheddar because I like that it gives a little extra bang of flavor.

sauce in a skillet for chicken spaghetti casserole

It melts into the sauce nicely.

making chicken spaghetti casserole in a skillet

Mix in chopped, cooked chicken and the pasta.

adding tabasco sauce to chicken spaghetti casserole

Add some tabasco for flavor. And salt and pepper…

making chicken spaghetti casserole in a skillet, ready to pour it into a red and white casserole dish

Pour it into a greased baking dish.

chicken spaghetti casserole in a white casserole dish ready for the oven

It looks pretty, doesn’t it?

cup of shredded cheese in a white measuring cup above a casserole

More cheese.  I chose Monterey Jack.

chicken spaghetti casserole in a red and white casserole dish ready for the oven

Sprinkle it on the top.

chicken spaghetti casserole in a white dish just out of the oven

Bake it for a half hour or so, and it comes out all bubbly and hot and melty.

single serving of chicken spaghetti casserole in a red bowl garnished with fresh parsley

Dish it up and eat!

If you happen to be following the Weight Watchers WW plan, you’ll find a link to the WW Points on the recipe card below. It’s definitely not “really” a weight watcher kind of recipe, but if you’re on that sort of a diet and you feel like splurging, at least you know the details and can plan for it. I’m a firm believer in eating what you want on a diet (normal stuff in moderation). That’s what I did with this recipe. I like to have my one serving, and that’s it! Big side salad to go with. Perfect, and it is filling and satisfying too!

The Best Casserole Recipes:

chicken spaghetti casserole in a white dish just out of the oven
4.74 from 26 votes

Chicken Spaghetti Casserole

This casserole is pure comfort food. It's worth the extra half-hour at the gym!
Prep: 25 minutes
Cook: 35 minutes
Total: 1 hour
Servings: 6 servings
Save this recipe!
Get this sent to your inbox, plus get new recipes from us every week!
Please enable JavaScript in your browser to complete this form.

Ingredients

Instructions 

  • Preheat oven to 350°F. Spray a 2-quart casserole dish with nonstick spray.
  • Cook pasta according to package directions, but only cook it until it's al dente (you still want a little bite to it). Drain the pasta and set it aside.
  • Melt butter in a large, deep skillet over medium heat. Add mushrooms, onion, celery and bell peppers. Cook until the vegetables have softened, 4 to 5 minutes. In a medium bowl, mix milk and soup until smooth. Add this mixture to the vegetables in the pan. Stir in cheddar cheese. Continue to heat the mixture until the cheese has melted and the sauce is smooth. Add in chicken, pasta and tabasco, and season to taste with salt and pepper. Pour the mixture into the prepared casserole dish. Sprinkle Jack cheese on top.
  • Bake for 35 minutes, or until the casserole is hot and bubbly and golden brown.

Notes

  • *If you are counting WW points, prepare this recipe with reduced-fat cheeses.
  • *If you're trying to figure out a serving size for this casserole, simply use a knife to divide the pan into 6 equal servings. There's your serving size (it's pretty substantial)!
  • *Leftovers of this casserole are great for a couple of days after making it.
  • *Turn this casserole into a day-after- holiday meal by adding leftover turkey instead of chicken.

Nutrition

Serving: 1serving, Calories: 327kcal, Carbohydrates: 31g, Protein: 29g, Fat: 9g, Saturated Fat: 4g, Cholesterol: 52mg, Sodium: 492mg, Potassium: 455mg, Fiber: 2g, Sugar: 5g, Vitamin A: 685IU, Vitamin C: 19mg, Calcium: 273mg, Iron: 1mg

Nutrition information is automatically calculated, so should only be used as an approximation.

Like this? Leave a comment below!
4.74 from 26 votes (10 ratings without comment)

Leave a comment

Your email address will not be published. Required fields are marked *

Rate This Recipe




116 Comments

  1. Sandra says:

    I bet this would be really good made with tortilla chips instead of spaghetti – sort of like dinner chiliquillas (that seems to be a San Diego B-fast specialty). Or maybe corn tortilla strips.

  2. Bev Weidner says:

    I have just fainted. This is MY FAVORITE.

    Now I must figure out how to live this day after seeing this.

    Wow.

  3. Chris @ TheKeenanCookBook says:

    This looks awesome. This is going to be our Wednesday night dinner, when we both get in late and Baby Boy is tired and fussy.

  4. Lauren says:

    This looks great, Lori! Easy weeknight meal for sure!

  5. Anne Tierney says:

    Growing up we called this Tetrazini. It’s always been one of my favorite go-to recipes for ooey gooey cheesy comfort food. Makes me want to put it on my menu plan for next week!

  6. jenna says:

    this sounds great. what a quick dinner idea.

  7. Nelly Rodriguez says:

    I just made something close to this last week; add shiitake mushrooms, onions, garlic, peppers and so much cheese! It’s definitely a great comfort meal as well!

  8. Heather Johnson says:

    Seriously – I wnt to eat this right now!

    Awesome!

  9. Katrina says:

    This sounds lovely! Need to try this one.

  10. Jessica @ How Sweet says:

    i think this is my husband’s idea of heaven!